The feedback-loops between gender identity, real life experiences, cultural concepts, genes and hormones are complex and messy, but there is a growing consensus among scientists that hormones do play a role in the creation of transgender identities.
The main focus is on the pre-natal period, when that person is still in its mother’s womb, being exposed to hormones aimed at triggering the development of gender specific organs and a gender identity.
Mapping the genes of trans women
In a paper called “Genetic Link Between Gender Dysphoria and Sex Hormone Signaling” Madeleine Foreman, Lauren Hare, Kate York, Kara Balakrishnan, Francisco J Sánchez, Fintan Harte, Jaco Erasmus, Eric Vilain and Vincent R Harley reports on a research project including 380 transgender women who have transitioned and 344 control male subjects.
They have looked at associations and interactions between variants of 12 sex hormone–signaling genes and gender dysphoria in transgender women.





